![]() ![]() The general rule for a rotation by 90 about the origin is AB -B A A rotation by 180 about the origin can be seen in the picture below in which A is rotated to its image A. Rotative is attested from 1778 as rotating from French rotatif from Latin rotativus.ġ80 Degree Rotation. Rotations About The Origin When rotating a point 90 degrees counterclockwise about the origin our point Axy becomes A-yx. You could rotate it in either direction like a steering wheel. Sense of pertaining to or consisting in rotation is by 1891. When we rotate a figure of 180 degrees about the origin either in the clockwise or counterclockwise direction each point of the given figure has to be changed from x y to -x -y and graph the rotated figure. The rectangle ABCD has been rotated 180 about the origin the direction is not required because it is a. ![]() In other words switch x and y and make y negative. ![]() Rotation about the Origin is a transformation that rotates or turns a figure eg a triangle about the origin point xy00. Rotation of a point through 180 about the origin when a point M h k is rotated about the origin O through 180 in anticlockwise or clockwise direction it takes the new position M -h -k. About The Origin When rotating a point 90 degrees counterclockwise about the origin our point Axy becomes A-yx. Worked-out examples on 180 degree rotation about the origin. The general rule for -270 degree rotation about the origin is x y becomes -y x. Let K -4 -4 L 0 -4 M 0 -2 and N -4 -2 be the vertices of a rectangle. This means the x and y will be switched and the y will be multiplied by -1. Y -x 90 degree rotation clockwise about the origin. If you rotate the whole plane 90 degrees to the left then the old x-coordinate. When we rotate a figure of 90 degrees about the origin each point of the given figure has to be changed from x y to -y x and graph the rotated figure. This means we switch x and y and make x negative. ![]() If you rotate the whole plane 90 degrees to the right then the old x-coordinate. Learn vocabulary terms and more with flashcards games and other study tools. Rotation about the Origin is a transformation that rotates or turns a figure eg a triangle about the origin point eqx y rightarrow 0 0. #90 CLOCKWISE ROTATION HOW TO#How To Perform Rotations The Easy Way Mouse Over To Start A rotation by 90 about the origin can be seen in the picture below in which A is rotated to its image A. Transformations Rotate 90 Degrees Around The Origin Youtube What does it mean to rotate something 180 degrees about the origin.
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![]() ![]() Nucleic acid-based agents, such as antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) have successfully provided high efficacy in preclinical studies and some of them have been approved for clinical trials. Alternative approaches, such as monoclonal antibodies, have tried to overcome this drawback, but their operating range is limited to extracellular or cell surface targets ( Lazo and Sharlow, 2016).Īdditionally, other strategies acting at the genetic level can be used to knockdown intracellular proteins, including scaffolding proteins, transcription factors, and non-enzymatic proteins ( Valeur et al., 2017). Nevertheless, a wide variety of proteins do not completely fulfill this characteristic and are considered “undruggable,” thereby representing challenging targets. Historically, the pharmacological intervention focused on targets with well-defined active sites suitable for the accommodation of a small molecule. The use of small-molecules for target modulation represents a classical approach in drug discovery, with a proven track record up to clinical use on a plethora of biological targets. ![]() Herein, we report a comprehensive record of PROTAC design, pharmacology and thermodynamic challenges and solutions, as well as some of the available strategies to enhance cellular uptake, including suggestions of promising biological tools for the in vitro evaluation of PROTACs permeability toward successful protein degradation. Despite these promising results, PROTACs are often affected by poor cellular permeability due to their high molecular weight (MW) and large exposed polar surface area (PSA). This modality has emerged as an orthogonal approach to the use of small-molecule inhibitors for knocking down classic targets and disease-related proteins classified, until now, as “undruggable.” In early 2019, the first targeted protein degraders reached the clinic, drawing attention to PROTACs as one of the most appealing technology in the drug discovery landscape. Proteolysis Targeting Chimeras (PROTACs) are heterobifunctional degraders that specifically eliminate targeted proteins by hijacking the ubiquitin-proteasome system (UPS). 2Pharmaceutical Biochemistry/Chemistry, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland.1School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.Carlotta Cecchini 1,2 †, Sara Pannilunghi 1,2 †, Sébastien Tardy 1,2 and Leonardo Scapozza 1,2 * ![]() ![]() ![]()
He grows very fond of Nancy over the course of the game. Always polite and very shy, Dave is a man of frustratingly few words who is mainly concerned with doing his job and doing it well.
![]() Designed to withstand the stresses of sharp rotary tools, this mat will help deliver reliable cuts again and again. Olfa RM-MG 24'x36' Self Healing 1.5mm Thick Rotary Cutting Mat (+69.99) Kai CB1 Gridded Cutting Mat 24x36' Dura Self Heal for Rotary Cutters (+49.99) Grace TrueCut Double Sided Rotary Cutting Mat 24x36' Gridded (+59.95) Fiskars F83727 24x36' Self Healing Rotary Cutting Mat, Grid, Bias Lines (+64. Add to Cart 30. Multipurpose Craft Cutting MatOur sewing cutting mat is perfect for sewing, crafts, modeling, quilting, fabric, scrapbooking. The large size makes it perfect for most crafting projects. 24 INCH BY 36 INCH MAT - This rotary cutting mat is 24'x36' and 1.5mm thick. Perfect for small, medium and large craft and sewing projects. The solid color side is used for general cutting. #Olfa 36x24 gridded cutting mat professionalA variety of sizes are available for your crafting or sewing workspace.Įxecute clean and precise cuts utilizing the gridded surface on one side of the mat while reserving the solid-colored opposite side for general purpose cuts. This professional grade rotary mat is used to protect your work surface and helps keep your blade from becoming dull. Olfa RM-MG Cutting Mat, 24' x 36' Green Green 24' x 36' Cutting Mat designed specifically for rotary. Perfect SizeHTVRONT large cutting mat measures approx 12 x 18 inch (A3 size), this cutting mats for crafts are durable and reusable. The Cutting Mats (4896DP and 60120DP) Print on Grid are not recommend for use with rotary cutters. Custom cut mats and grids are not returnable. The 1.5 mm surface of this OLFA mat pulls itself back together like magic so that your next cut is steady and clean. Used in conjunction with rotary cutters, this double-sided mat is essential for the OLFA cutting system. Mats and Mats with grids can be cut to custom size, priced from standard size. #Olfa 36x24 gridded cutting mat freeWith free speedy delivery in the UK on all haberdashery, and sewing supplies. This sturdy mat is ideal for daily use in your most demanding craft projects. Buy Olfa Craft Cutting Mats & Rotary Cutting Mats Online at .uk. Has a 2' wide marking for cutting a bias strip. Includes 45-degree bias lines and a 30, 60, and 90-degree angle line. One side of green mat has yellow 1/8' hash marks and 1' grid marks which go all the way to the edge of the mat. Use either side for cutting surface - it's self-healing on both sides. ![]() The gridded area features markings to measure up to 24' x 36'. ![]() The solid green color on one side is for general crafting, while the other side has grid lines marking inches for detailed cutting. Store mats flat sensitive to excessive heat. The self-healing OLFA 24" x 36" Green Double-Sided Rotary Mat keeps your work surface clean and provides a durable and smooth surface for every cut. The self-healing finish reseals surface cuts, providing a continually smooth surface for all cutting projects. ![]() ![]() Here's a quick post to relax your nerves ever so slightly. but the surround cupboards are currently bare. The only thing dampening the outlook of the upcoming championship-potential season for the UK basketball squad is the fans worrying about the Wildcats' nonexistent 2012 recruiting class. Goodwin has potential to be a very good defender and rebounder as well, but should work on getting stronger to maximize that potential. He also has good range and is capable of knocking down three pointers. ![]() He is a solid ball handler who does a good job of getting to the rim and finishing. #3 SG (behind Ricardo Ledo and Rodney Purvis), #9 Overall, Grade - 97Įvaluation: Archie Goodwin is a skilled shooting guard with good length and athleticism. #3 SG (behind Marcus Smart and Ricardo Ledo), #12 Overall, Grade - 97 He is a producer that continues to climb the recruiting ranks. Goodwin has blown up on the radars of major colleges simply because he played his way there. His team always seems to be in the final game of the tournament thanks in part to his competitive nature and unselfish play. Bottom Line: No player has taken advantage of the spring and summer evaluation periods to burst onto the national scene than Goodwin this kid is a player and a winner. Natural maturity will add 10-15 pounds to his long frame, but Goodwin needs to sell out in the weight room and he should make a major impact on the next level. He has all to tools to play the shooting guard position if he can be more consistent with his stroke and create for others off the bounce. However, because he is so difficult to defend off the dribble he needs to continue to groove his shot from behind the arc and perfect his pull-up game as opponents give ground. ![]() Weaknesses: Goodwin's game is tight for a young player with no glaring flaws. Goodwin has a nice handle that gets him where he needs to go, and has improved his perimeter stroke from behind the arc. It looks as if all facets of the game come easy to him. He has tremendous length on his side which he utilizes to rebound and defend. ![]() Goodwin is a multi-skilled forward who can put the ball on the floor to attack the rim or spot up for knock-down jump shots out to the 3-point arc. Strengths: The long athletic small forward has brought back comparisons of the last great player from the state in Joe Johnson because of the smooth way he plays the game. #4 SG, behind Gary Harris, Marcus Smart, and Rasheed Sulaimon Overall he's a talented scorer with some serious potential. At this stage, Goodwin is a good shooter, but could still extend his range. Goodwin gets after it on both ends and plays with intensity of the defensive side of things. One of the better two-guards in the 2012 class, Goodwin, who stands 6-foot-4, possibly 6-foot-5, made his bones by attacking the basket and always playing an aggressive brand of basketball. Strengths: Attack Mode, Competitiveness, Defensive PresenceĪreas for Improvement: 3-Point Range, Strength #3 SG, behind Rasheed Sulaimon and Gary Harris from Little Rock, ArkansasĪveraged 28.3 points, 7.0 rebounds, 2.5 assists, and 3.0 steals as a junior with Arkansas Wings travel team. ![]() ![]() It’s like banging your head against a brick wall. We are asking a demented, violent predator who thinks that they are a saint or a superhero, to accept responsibility. We keep forgetting that directly talking about race is a waste of our breath. They feel that we should be thanking them for all that they have done for us. We are now in a psychological predicament, because white people feel that we are bullying them when we bring up race. White people are out of their minds and they have been for a long time. I had fantasies of unloading a revolver into the head of any white person that got in my way, burying their body, and wiping my bloody hands as I walked away relatively guiltless with a bounce in my step. The cost of your own life, as they suck you dry. This is the cost of talking to white people at all. Here are some of the quotes from the lecture: But looking at the doctor’s social media, it seems completely genuine. When I listened to the talk I considered the fact that it might be some sort of elaborate prank. ‘The Psychopathic Problem of the White Mind’Ī psychiatrist lecturing at Yale’s Child Study Center spoke about ‘unloading a revolver into the head of any white person that got in my way.’Ī few weeks ago, someone sent me a recording of a talk called “The Psychopathic Problem of the White Mind.” It was delivered at the Yale School of Medicine’s Child Study Center by a New York-based psychiatrist as part of Grand Rounds, an ongoing program in which clinicians and others in the field lecture students and faculty. ![]() ![]() Earlier: Aruna Khilanani, Child Of Privileged Immigrants, Hates The White People She Was Raised WithĮverybody is talking about some lady psychoanalyst of Pakistani descent who gave a speech at Yale Law School on “The Psychopathic Problem of the White Mind” that sounds like some 1980s Eddie Murphy routine about “ Kill My Landlord” or “ Kill the White People.” ![]() ![]() ![]() (SketchMee has a companion iPad app for $5, and there is also PaintMee, a $3 iPhone app. With SketchMee, though, it looked almost lovely. The framing was typically horrible and the flash reflected off of a cabinet behind my son. I had recently taken a shot of my two youngest children with a friend. You can adjust the pencil strokes in eight ways, and each option includes a brief tutorial that increases your odds of making art. This app turns your photos into pencil sketches of remarkable quality. IPhone app developers can create programs for one platform and just a few (very powerful) devices, and sell them on what is arguably the best software market, iTunes. ![]() For people who are contemplating their next phone, the broader issue here may be worth quickly noting. On BlackBerry, Picture Magic ($5), Doodle ($1) and PhotoColor ($3) are worth a look.Īs is almost always the case, there are more, and better, apps in this category for iPhone users than for those with Android or BlackBerry devices. #Sketchmee for android for androidFor Android are free apps like PicSay and Pic Paint. The short list includes, for Apple users, ToonPaint ($2), SketchMee ($3 for iPhones, $5 for iPads), Unicorn Shots ($1) and Color Splash ($2). But I recently stumbled onto something far more useful: apps that take your lousy shots and help you turn them into something ridiculous, bizarre or maybe even beautiful. The various app markets brim with software to help people like me. I rarely take photos with my phone because I am a lousy enough photographer with a real camera. ![]() ![]() ![]() ![]() I would recommend this recording of this book, but be aware of what you’re getting yourself into beforehand. Nonetheless, the writing is strong enough that a careful listener can work around the narration. With Hodor the failure is less distracting, since he only says one word anyway, but Yoren is consistently annoying and hard on the ear in every scene. Also worth mention are his terrible performances as Hodor the stableboy and Yoren the black brother. Dotrice and an absolute failure to grasp the character. His most distracting and consistent failures come with two of the most important characters, Tyrion Lannister (who is given to sound like a shamefully caricatured leprechaun) and Lord Varys, whose sloppy annunciation and unmstakeable lisp are a shame to Mr. He miserably fails at voicing literally every female character in the book, especially Brienne of Tarth and Mellisandre, and he manages to butcher most of the younger characters, including Theon Greyjoy and Bran Stark. That being said, the list of characters who are nearly destroyed by his flamboyant voicing is long and unfortunate. Similarly, the voice he uses to narrate the general text itself is deliberate and clear. Some characters, mainly the older male characters, are given excellent voices. That being said, Dotrice’s narration is, to say the least, a mixed bag. Nonetheless, if you’re here for more of what you got in “A Game of Thrones”, you’ll find plenty. His use of different perspectives to tell the story is refreshing, but there are certain characters that it seems should be added to that list who remain absent, while some characters can grow simply tiresome at times. The writing is strong, but the pace of the story is at once somehow quick, drawing the ear to the next page, and painfully slow. #The clash of kings audiobook seriesWhat did you like best about A Clash of Kings? What did you like least? Martin’s series is grand and ambitious in its scope, and that is simultaneously its blessing and its curse. Robin – Problematic, but good on the whole. I’m excited about the series and will be more than ready to move on after book 3. Any additional comments? Just finishing up book 2. Was this a book you wanted to listen to all in one sitting? 37 hours N/A. Then he snaps you out of it like being awakened from a sleep by a power saw in your bedroom. You find yourself lost in the story till it comes time to narrate a female part. His voice is excellent for reading the back story. That said Roy has the perfect amount of drama. It’s getting quite old and it’s very disappointing. The remainder of male characters sound like grumpy Leprechauns. But! his females all sound like toothless old crones in pirate movies. Who would you have cast as narrator instead of Roy Dotrice? Roy does 2 or 3 voices voices very well. Will he stay humble? It seems like a question Tyrion would ask himeself. He’s coming up in the world and doing big things. Obvious underdog, bullied his whole life. ![]() Who was your favorite character and why? Tyrion Lannister. Would you listen to A Clash of Kings again? Why? No. ![]() ![]() Up to four gamers can join together either locally or online to fight against a horde of zombies. Some of the perks in this Xbox 360 title include seeing your opponents through walls and new guns.This Xbox 360 title also marks the return of the cooperative Zombies mode. This mechanic allows defensive players to earn just as many rewards as offensive ones. Rather than reward gamers who obtain kills without dying, you'll get rewards by earning points. This Black Ops title for the Xbox 360 also changes the Killstreak system, which has been renamed to Scorestreaks. #Call of duty 2 for x box 360 fullFor example, you can load your weapon full of attachments at the cost of not selecting any grenades. You can choose 10 weapons and accessories from a list, with each choice taking up one slot. The Pick 10 system allows you to refine your character in any way you wish. The first significant change to this Call of Duty title is the character creation. This Xbox 360 Call of Duty title also features a multiplayer mode that is much more different than before. The game will move forward acknowledging that character's death and will adjust the story accordingly. In other words, when your character dies in the game, you don't get the option to restart. This Black Ops title also features permanent death. These missions have a permanent impact on the story. Taking one mission will lock you out of doing the others, so choose wisely. During the single-player campaign, players are frequently given a choice of which mission they want to undertake. ![]() Your weapons range from the standard pistols and machine guns to all-new futuristic weapons like militarized drones. As a first-person shooter, you'll wield a variety of weaponry. This Black Ops title features gameplay similar to the previous games in the franchise. ![]() This game was developed by Treyarch and published by Activision. #Call of duty 2 for x box 360 seriesThis Call of Duty title is also the first game in the series to feature non-linear gameplay sections along with multiple endings. The game frequently switches between time periods, showing you how the events in 1986 had an effect on 2025. Half the action takes place in 1986 while the other half takes place in 2025. The campaign is separated into two time periods. However, Black Ops 2 has taken the franchise to the future for the first time. In past games, the action took place in either the past or the present. |
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